Topical Lipid Film Forming Gels: Prospects for Enhanced Dermal Delivery

Praghna M.R, S. Rajarajan, Beny baby, K. Ramesh

Dermal drug delivery localizes therapeutic agents at the site of action while minimizing systemic effects, but the skin barrier limits drug penetration. This review explores lipid-based film-forming gels as an innovative approach to enhance drug absorption, particularly for melanoma treatment. Film-forming systems (FFS) create an in situ polymeric film upon application, allowing sustained drug release and improved adhesion. Lipid-based formulations integrate with the skin’s lipid matrix, facilitating deeper penetration. Permeation enhancers, liposomes, and nanocarriers further augment drug absorption. Techniques like micro needles, electroporation, and sonophoresis help overcome skin barrier limitations. Recent advancements focus on optimizing film-forming gels for controlled drug delivery. Despite advantages, challenges like formulation stability and variability in skin permeability persist. Future research should refine formulations and integrate advanced technologies for improved therapeutic outcomes. Personalized dermal therapies may revolutionize melanoma treatment, offering more effective and convenient alternatives.

Keywords – Lipid-based film-forming gels, transdermal delivery, electroporation, liposomes.